منابع مشابه
Pharmacological studies on fatigue. I.
Considerable investigation has been done as to whether or not a particular drug is effective for recovery of an animal after it has become exhausted. Experiments have included screening antifatigue effect on animals, but applications have not been generally established. Effects of drugs on psychological fatigue as seen in man can hardly be inferred from tests on animals. Even physiological effe...
متن کاملIsothermal Titration Calorimetry and Molecular Dynamics Simulation Studies on the Binding of Indometacin with Human Serum Albumin
Human serum albumin (HSA) is the most abundant protein in the blood plasma. Drug binding to HSA is crucial to study the absorption, distribution, metabolism, efficiency and bioavailability of drug molecules. In this study, isothermal titration calorimetry and molecular dynamics simulation of HSA and its complex with indometacin (IM) were performed to investigate thermodynamics parameters and th...
متن کاملAccelerated titration designs for phase I clinical trials in oncology.
BACKGROUND Many cancer patients in phase I clinical trials are treated at doses of chemotherapeutic agents that are below the biologically active level, thus reducing their chances for therapeutic benefit. Current phase I trials often take a long time to complete and provide little information about interpatient variability or cumulative toxicity. PURPOSE Our objective was to develop alternat...
متن کاملTheoretical studies on force titration of amino-group-terminated self-assembled monolayers
The structures of (3-aminopropyl)triethoxysilane (APTES), 4-aminothiophenol (4-ATP) and 4-mercaptopyridine (4-MP) self-assembled monolayers (SAMs) are studied by quantum mechanics in order to explain the force titration curves of these amino-group-terminated SAMs. The surface charges and electrostatic surface potentials derived from the ab initio calculations can give satisfactory explanations ...
متن کاملThe Effect of Denaturing Agents on Myosin* I. Sulfhydryl Groups as Estimated by Porphyrindin Titration
Myosin is a protein distinguished by its very high viscosity and intense double refraction of flow. It is also one of the few proteins which possess titratable sulfhydryl groups even in the native state; in the presence of certain denaturing agents the number of such groups is very greatly increased. Study of the action of a large number of denaturing agents on myosin has revealed certain pheno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1961
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.81.9_1303